Functional and Clinical Aspects (Advances in Experimental Medicine and Biology)

Publisher: Springer

Written in English
Cover of: Chromogranins |
Published: Pages: 426 Downloads: 343
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Edition Notes

ContributionsKaren B. Helle (Editor), Dominique Aunis (Editor)
The Physical Object
Number of Pages426
ID Numbers
Open LibraryOL9536089M
ISBN 100306464462
ISBN 109780306464461

Antibodies specific for chromogranin A, B or C have been used to detect immunohistochemically these three anionic proteins. Pancreatic A, B and PP cells, gut argentaffin EC, argyrophil ECL and gastrin G cells, thyroid C cells, parathyroid cells, adrenal medullary cells, pituitary TSH, FSH and LH cells as well as some axons of visceral nerves have been found to react with chromogranin A . The neuroendocrine (NE) system may play an important role in smoking-induced airway diseases. The aim of the present study was to examine the relationship between serum levels of the general NE marker chromogranin A (CgA) and smoking habits, respiratory symptoms and lung function. The study population consisted of never-smokers with normal lung function, smokers with . Chromogranin A (CGA) is the major soluble protein within secretory vesicles of chromaffin cells. A polyclonal antiserum was raised against bovine CGA and characterized in two-dimensional immunoblots. Cellular and subcellular distribution of CGA in bovine pancreatic islet was investigated by immunocytochemistry. Chromogranin A (CgA) is found throughout the diffuse neuroendocrine system and is thought to be the best and most sensitive general marker for the diagnosis and follow-up of NETs, with a sensitivity of 96% and 75% in functioning and non-functioning NETs, respectively, and a specificity of %. Immuno-histochemical detection of CgA.

(biochemistry) Any of a family of secretory proteins found in many types of cell. plural of chromogranin Definition from Wiktionary, the free dictionary.   Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed).Displays antibacterial activity against Gram-positive bacteria and , and Gram-negative bacteria and nosa (PubMed and PubMed).Can induce . Making Health Communication Programs Work (Pink Book) A guide to communication program planning that includes strategy development, testing concepts and materials, implementing programs, and more.

Chromogranins Download PDF EPUB FB2

Rohit Bhargava, David J. Dabbs, in Diagnostic Immunohistochemistry (Third Edition), Chromogranins. The chromogranins (types A, B, and C) are a group of monomeric proteins that compose the major portion of the soluble protein extract of the neurosecretory granules of neuroendocrine cells; chromogranin A, with a molecular weight of 75 kD, is the most.

Chromogranin A (CgA) is a protein released from neuroendocrine cells. These are cells that release hormones in response to signals from the nervous system.

They are found in organs throughout the body. This test measures the amount of chromogranin A in the blood.

Kevin Foskett, Don-On Daniel Mak, in Current Topics in Membranes, C Chromogranins. Chromogranins are high-capacity, low-affinity Ca 2+ binding proteins that are enriched in secretory granules Chromogranins book are also found in ER and nuclear compartments (Aunis & Metz-Boutigue, ).Both chromogranins A and B (CGA/CGB) interact within the third lumenal loop of IP 3.

Chromogranin A is a secretory protein. It is located in the large, dense-core vesicles of neuroendocrine cells. Chromogranin A-derived peptides are involved in a range of activities, like glucose metabolism, tumour angiogenesis, regulation of blood pressure and Chromogranins book.

Neuroendocrine cells. This book deals with the chromogranins, secretory prohormones from the Chromogranins book neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, Chromogranins book emphasis on the functional aspects of the biologically.

Chromogranin A is elevated to several times the upper limit of the reference range in 90% of patients with carcinoid syndrome.

Chromogranin A is particularly useful for diagnosing mid and hindgut carcinoid tumors, since they may not secrete serotonin and 5-HIAA. Chromogranin A may be used to detect residual or recurrent disease in treated patients.

The Chromogranin A [CgA] blood test is ordered when there is a suspicion of a carcinoid syndrome present within a patient. It may also be routinely ordered to monitor the treatment of such a syndrome.

Chromogranins book In its early stages, carcinoid syndrome can be very difficult to detect. Many of the signs and symptoms of it. The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell biology, physiology and biomedicine.

The different chapters highlight novel activities of these proteins, including their. Chromogranin A (CgA) is a general marker associated with all carcinoid tumors. It is a protein produced by tumor cells and released.

Chromogranin A is associated with other hormones and may be involved in their regulation. It may also be associated with cell adhesion in metastatic disease. It is deposited directly into the vascular compartment. There are various causes of elevated chromogranin A (CgA) levels that are unrelated to neuroendocrine tumors.

The most common causes of non-neuroendocrine tumors (false-positive result) encountered in the clinical practice is the use of proton pump inhibitors (PPIs), atrophic gastritis cases and impaired kidney function.

Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins, i.e., it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in pancreas.

In humans, chromogranin A protein is encoded by the CHGA gene. The following is a collection of reference materials about Chromogranin A. The links in this document are to abstracts, unless noted. Chromogranin A, Neuron Specific Enolase, CEA, and Hydroxyindole Acetic Acid Evaluation in Patients with Neuroendocrine Tumors.

Bajetta E, et al. Cancer Sep 1;86(5) “There appears to be a direct correlation between tumor. Blood chromogranin A levels corresponding to normal hormonal processes in a healthy person, are relatively low. However, in the presence of hormone-secreting neuroendocrine tumors, chromogranin A levels can rise significantly; The Chromogranin A Blood Test is a test to assess the levels of chromogranin A in blood.

Chromogranin A - Chromogranin A (CgA) is used as an adjunct in the diagnosis of carcinoid tumors. Measurements of CgA are also used to assess disease progression, response to therapy, or recurrence after surgical resection.

Introduction: The predictive value of tumor grade in the prognosis of carcinoid is insufficient and somehow misleading. The grade and differentiation in carcinoid tumors must be seen in conjunction with the Ki index.

The Ki protein is a cellular marker for proliferation, present during all active phases of the cell cycle (G1, S, G2 and mitosis) and absent from resting cells. The volume is designed to provide an integrated overview of the results from the last fifteen years of research on Chromogranins in relation to cell.

This book deals with the chromogranins, secretory prohormones from the diffuse neuroendocrine system. The current concepts of their structure, biogenesis, biosynthesis, secretion, tissue-specific distribution, and processing are presented for the first time all within one volume, with emphasis on the functional aspects of the biologically Manufacturer: Springer.

Chromogranin A concentrations are normally low. Increased concentrations in a symptomatic patient may indicate the presence of a tumour but will not tell the doctor what type it is or where it is.

The quantity of CgA is not associated with the severity of a patient’s symptoms but is associated with the tumour burden – the mass of the tumour. The reference range for chromogranin A is 15 so if you are below that it's in the normal range. I wouldn't worry at all about an ultra low value - wish I had it.

chromogranin can be quite variable and subject to diet, prescription drugs etc. Mine has been all over the place for 4 years with the lowest being 36 and the last one when the MRI. Chromogranin A (CgA) is an acidic glycoprotein with a molecular mass of 49 kd that is widely expressed by neuroendocrine cells and constitutes one of the most abundant components of secretory granules.

1 CgA is physiologically released by exocytosis and may be detected in the blood. In particular, when a tumor develops in an endocrine tissue, it becomes.

chromogranin: (krō'mō-gran'in), A soluble and secretory hormone proteins of chromaffin granules. Chromogranins A, an acidic glycoprotein, comprises about 50% of the total protein of the granule matrix.

Other types are chromogranin 13 and secretogranin II. The chromogranin A, ECL blood test is used to measure the amount of chromogranin A in the blood to detect ECL hyperplasia.

It should be notice that the normal range of CgA is ng/mL. Elevated levels of CgA may indicate tumors. Keywords: chromogranin a ecl blood test.

The chromogranin A (CgA) test is used as a tumour may be ordered in combination with a 5HIAA urine test to help diagnose carcinoid may also be used to detect the presence of other tumours arising from neuroendocrine cells.

Neuroendocrine cells are cells that have both nerve and hormone (endocrine) aspects and are found in organs throughout the body. To the Editor, Human chromogranin A (CgA) is a secretory protein that is used as a tissue marker for neuroendocrine tumors (NETs) (1,2).

In patients with carcinoids and pheochromocytomas, CgA is a. WHAT IS CHROMOGRANIN A. AND WHAT DOES IT MEAN A RESULT OF IN A BLOOD TEST RESULTS - Answered by a verified Doctor. We use cookies to give you the best possible experience on our website. By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them.

Chromogranin A Monoclonal Antibody (LK2H10), Biotin. 25 References 25 References 6 figures. Target. Human Non-human primate Pig Rabbit Rat. Details. Mouse Monoclonal. Application. ICC IF IHC (P) WB. Price.

Online offer: Cat # MA µL. Compare. Invitrogen. Chromogranin A Monoclonal Antibody (23A1). What does chromogranin mean. A spoken definition of chromogranin.

Intro Sound: Typewriter - Tamskp Licensed under CC:BA Outro Music: Groove Groove - Kevin MacLeod () Licensed. Function. Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells.

The exact function(s) of these proteins is not yet settled but there is evidence that granins function as pro-hormones, giving rise to an array of peptide fragments for which autocrine, paracrine, and endocrine.

The goal has been to draw the main lines of progress in the chromogranin field, from the early discoveries towards our current understanding of the functional implications.

It. chromogranins: Calcium-binding glycoproteins found in the secretory granules of all endocrine glands. The are cleaved to form biologically-active peptides. Acid reflux is one of the most common reasons why my patients visit me in my office in Michigan.

Recent statistics from the American College of Gastroenterology say that 60 million Americans experience heartburn at least once a month, with 15 million having symptoms of acid reflux or GERD every single day. (5) There’s a certain type of reflux that is referred to as “silent” reflux.Request PDF | Chromogranins: From the discovery to the function | Granins are proteins constituents of dense core secretory granules in endocrine and .chromogranin definition: Noun (plural chromogranins) 1.

(biochemistry) Any of a family of secretory proteins found in many types of cell.