biological fate of vinylidene chloride in mammals. by Brian Keith Jones Download PDF EPUB FB2
Comparative investigation of the biological fate of vinylidene chloride reveals an agent of low oncogenic potential which is likely to be damaging only under special circumstances, and species differences which suggest that the mouse is more susceptible than the rat towards vinylidene chloride sofianatsouli.com by: The main eliminative route for [14 C]vinylidene chloride ([14 C]DCE) after intragastric, i.v.
or i.p. administration to rats is pulmonary; both unchanged DCE and DCE-related CO 2 are excreted by that route and other DCE metabolites via the sofianatsouli.com of the urinary 14 C is of biliary origin.
After intragastric dosing, the plot of the pulmonary output of unchanged DCE against the logarithm of Cited by: The biological fate of vinylidene chloride in mammals. Author: Jones, B. ISNI: Awarding Body: University of Bradford Current Institution: University of Bradford Date of Biological fate of vinylidene chloride in mammals.
book Availability of Full Text: Access from EThOS. Linear-log plot of the pulmonary excretion of unchanged vinyl chloride against the reciprocal doses. Five groups of 3 rats were dosed i.g.
with vinyl chloride at dose levels in the range of 1 to mg/kg; each point represents 3 independent values. The first one concerns the fate of a dose of vinyl chloride in the mammalian sofianatsouli.com by: Vinylidene chloride is weakly positive in the Salmonella typhimurium TA test, mediated by kidney and liver post-mitochondrial supernatant (S-9 mix) from normal mice, but strongly positive with the S-9 mix from the induced animals.
In the case of mediation by rat tissue, only liver S-9 mix from induced animals affords a significant positive sofianatsouli.com by: Oct 15, · Evidence for alkylation of DNA has been provided for vinyl chloride, 1 vinylidene chloride, 2 and trichloroethylene 3,4 Rearrangement mechanisms have been studied in detail 5 and found mostly consistent with the spectrum of metabolites found in vivo, 6 and mercapturic acids have been demonstrated as the main metabolites of vinyl and vinylidene Cited by: 5.
The mutagenicity of vinyl chloride, vinylidene chloride (1,1-dichloroethylene) and chloroprene (2-chloro-1,3-butadiene) was tested in V79 Chinese hamster cells in the presence of a 15 × g liver supernatant from phenobarbitone-pre-treated rats and mice. Mutations in terms of 8-azaguanine and ouabain resistance were induced in a dose-related fashion by exposure to vapour of vinyl chloride Cited by: The biological fate of vinylidene chloride in rats.
Chem. Biol. Interact. 20, 27– Google Scholar Kafer, E. and Kappas, A. () Genetic analysis of genotoxic effects on chromosomes and cell division in lower sofianatsouli.com: A.
Kappas, V. Cogliano, K. Watanabe, G. Zapponi. The metabolism of inhaled vinylidene chloride in rats represents a balance of biotransformation pathways leading to the formation of a reactive alkylating species which is normally detoxified by conjugation with sofianatsouli.com by: ABSTRACT Vinylidene chloride is toxic to laboratory animals and can be fatal at sufficiently high dose levels.
Liver is the prime target organ of vinylidene chloride in mammals. Hepatic injury can occur rapidly^ after inhalation exposure. Chronic exposure to low levels of vinylidene chloride can result in liver and kidney damage.
Chlorinated aliphatic hydrocarbons constitute a variety of chemically closely related compounds which share one common physical feature: D.
The biological fate of vinylidene chloride in rats. Chem.-Biol. Interact., 20, 27 PubMed CrossRef Google Scholar. Laib, R. and Bolt, H. Buy this book on publisher's site Cited by: 3. Male rats (normally fed or previously fasted for 18 hr) were given a single oral dose of 1 or 50 mg/kg of [14 C]vinylidene chloride (VDC) in corn oil and the routes and rates of elimination of 14 C activity were then followed for 72 sofianatsouli.com a single oral dose of 1 mg/kg of [14 C]VDC, 78% of the dose was metabolized and excreted in urine and feces as nonvolatile metabolites of sofianatsouli.com by: The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites.
The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Oct 15, · Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Abstract D.E.: The biological fate of vinylidene chloride in rats.
Chem.-biol. Interact. 20, 27–41 () CrossRef Google Covalent Binding of Haloethylenes. In: Snyder R. et al. (eds) Biological Reactive Intermediates—II. Advances in Cited by: 7. 1,1-Dichloroethylene (DCE), also known as vinylidene chloride, DC, 1,1-DCE, and 1,1-dichloroethene, has been used as a chemical intermediate and in the manufacture of poly vinylidene copolymers.
Polymers of DCE and vinyl chloride are used as food wrap (CEH ). DCE is a synthetic chemical with no known natural sources (USEPA ).Cited by: 5. The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites.
The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is sofianatsouli.com by: Exposure of mice to 50,or ppm of vinyl chloride (VC) in the air for 6 h/d, 5 d/wk, caused a high incidence of bronchioloalveolar adenoma, mammary gland tumours, and hemangio & arcoma.
Mammary gland tumours occurred in the females and included ductular adenocarcinoma and squamous and anaplastic cell carcinomas with metastasis to the sofianatsouli.com by: PubMed:The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride.
Vinylidene chloride polymers are widely used as food wrappers. This review, with 38 references, covers chemistry, and animal and human toxicology.
Biosensors and Biological Nanotechnology - (WW) mammals mammals Subject Category: Organism Names see more details, Cited by: 9. Drug Metabolism and Disposition will consider for publication manuscripts describing the results of original research that contribute significant and novel information on xenobiotic metabolism.
The present report deals with the early results of carcinogenicity bio-assays of Vinylidene chloride (VDC), weeks from the starting of the experiments, VDC is employed in the production of polymers, whose major use is the manufacturing of flexible packaging for food.
" The monomer has been tested by inhalation on rats (,50, 25, 10 ppm), mice (,50, 25, 10 ppm), and Cited by: Vinylidene chloride was, however, toxic to yeast.
No information was found concerning the toxicity of vinylidene chloride to domestic animals and non- aquatic wildlife. Biological Effects in Animals and Man Vinylidene chloride is readily absorbed by mammals following oral or inhalation exposure. Chlorinated ethylenes are metabolized in mammals, as a first step, to epoxides.
The fate of these electrophilic intermediates may be reaction with nucleophiles (alkylation), hydrolysis, or intramolecular rearrangement. The latter reaction has been studied in the whole series of chlorinated epoxiethanes. 1,1-Dichloroethylene (1,1-dichloroethene, vinylidene chloride, 1,1-DCE) is a clear, colourless liquid with a characteristic sweet odour, a boiling point of approximately 32°C, a high vapour pressure of kPa at 20°C and a Henry's law constant of atm·m 3 /mol.
Footnote 1 Footnote 2 It is soluble in most organic solvents, and its solubility in water is mg/L at 21°C. Toxicity of vinylidene chloride in mice and rats and its alteration by various treatments. Robert D. Short, Potential biological hazards of commercially available cleansers for dentures.
Robert E. Osterberg, Book Reviews. book review. Book review. John S. Krebs & David C. Jones. Fifty-four abstracts of papers that discuss the physical properties, chemical reactions, and toxicity of vinylidene chloride (VDC) are presented. An overview summarizes data on the effects of acute and chronic exposures of rats by inhalation or ingestion, mutagenicity in Salmonella typhimurium, and skin and eye irritation and neurological.
Vinylidene chloride was quantifiable, exceeding approximately 1 mg/m 3 only occasionally (Vinylidene chloride concentrations in the µg/m 3 ( ppb) range were measured at urban sites in New Jersey as part of the Airborne Trace Element and Organic Substances (ATEOS) project [68, 69]. However, the authors.
Vinylidene chloride (VDC) is a groundwater and drinking water contaminant. Monochloroacetic acid (MCA) is a chlorination by-product of drinking water. Because environmental or occupational exposure to chemicals takes place at low concentrations, a sensitive in vitro system of liver slices was used to examine the interactive toxicity of MCA and sofianatsouli.com by: 3.
For this study by the medical department of a large chemical company the authors identified workers who had been exposed to vinylidene chloride (VCl2) but not to vinyl chloride (VCI). In previous studies relating to exposure to VCI and health there had also been some VC12 in the working environment, and although animal experiments had shown VCl2 to be a hepatotoxin no reports on the effects of Cited by:.
Predicting the oral uptake efficiency of chemicals in mammals: Combining the hydrophilic and lipophilic range Article in Toxicology and Applied Pharmacology (1) · November with 57 Reads.Vinylidene chloride is readily absorbed by mammals following oral or inhalation exposure.
the atmospheric fate of vinylidene chloride under physical and chemical removal processes was studied by Cupitt (). No studies were found in the literature searched on the biological effects of vinylidene chloride on microorganisms.Abstract. Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial sofianatsouli.com by: