biological fate of vinylidene chloride in mammals.

by Brian Keith Jones in Bradford

Written in English
Published: Pages: 266 Downloads: 97
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Ph. D. thesis. Typescript.

The Physical Object
Number of Pages266
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Open LibraryOL13729653M

Jones BK, Hathway DE (a) The biological fate of vinylidene chloride in rats. Chemico-Biological Interactions, – Jones BK, Hathway DE (b) Differences in metabolism of vinylidene chloride between mice and rats. British Journal of Cancer, – 1,1-Dichloroethylene hepatotoxicity. Time course of GSH changes and biochemical aberrations Article (PDF Available) in American Journal Of Pathology (2) · December with 17 Reads. ABSTRACT A comprehensive survey of the world literature was conducted to pre- pare this report on the health and environmental impacts of vinylidene chloride. The available information indicates that vinylidene chloride may have significant health effects, but the information shows inconsistencies and is insufficient for the formulation of. Vinylidene chloride is a highly reactive, flammable, clear colorless liquid. In the absence of chemical inhibitors, it can produce violently explosive, complex peroxides.

Studies on vinyl chloride migrating into drinking water from polyvinyl chloride pipe and reaction between vinyl chloride and chlorine. Water Res., Antweiler, H. (). Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Environmental Fate and Effects Division, Washington, DC, () U.S. Environmental Protection Agency. Guidance for the Reregistration of Pesticide Products Containing Methoprene as the Active Ingredient. Jan 01,  · Read "Predicting the oral uptake efficiency of chemicals in mammals: Combining the hydrophilic and lipophilic range, Toxicology and Applied Pharmacology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The biological fate of vinylidene chloride in.

Print book: EnglishView all editions and formats Summary: A comprehensive resource for drug discovery and pharmaceutical research The Wiley Handbook of Current and Emerging Drug Therapies brings together, for the first time in a single resource, the most current information on drug discovery and pharmaceutical research. Get this from a library! Industrial and Environmental Xenobiotics: Metabolism and Pharmacokinetics of Organic Chemicals and Metals Proceedings of an International Conference held in Prague, Czechoslovakia, 27'30 May [Ivan Gut; Miroslav Cikrt; Gabriel L Plaa] -- The book you are just going to read represents the greater part of the papers presented at the International Conference on. Unit 1 Bio 2 (slides ) study guide by ashlynnemeia includes 97 questions covering vocabulary, terms and more. Quizlet flashcards, activities and games help you improve your grades. Alkylation of RNA by Vinyl Chloride and Vinyl Bromide Metabolites in Vivo: Effect on Protein Biosynthesis.- Effects of Ethanol, Diethyl Dithiocarbamate, and (+)-Catechin on Hepatotoxicity and Metabolism of Vinylidene Chloride in Rats.- On the Reaction of Vinyl Chloride and Interaction of Oxygene with DNA

biological fate of vinylidene chloride in mammals. by Brian Keith Jones Download PDF EPUB FB2

Comparative investigation of the biological fate of vinylidene chloride reveals an agent of low oncogenic potential which is likely to be damaging only under special circumstances, and species differences which suggest that the mouse is more susceptible than the rat towards vinylidene chloride by: The main eliminative route for [14 C]vinylidene chloride ([14 C]DCE) after intragastric, i.v.

or i.p. administration to rats is pulmonary; both unchanged DCE and DCE-related CO 2 are excreted by that route and other DCE metabolites via the of the urinary 14 C is of biliary origin.

After intragastric dosing, the plot of the pulmonary output of unchanged DCE against the logarithm of Cited by: The biological fate of vinylidene chloride in mammals. Author: Jones, B. ISNI: Awarding Body: University of Bradford Current Institution: University of Bradford Date of Biological fate of vinylidene chloride in mammals.

book Availability of Full Text: Access from EThOS. Linear-log plot of the pulmonary excretion of unchanged vinyl chloride against the reciprocal doses. Five groups of 3 rats were dosed i.g.

with vinyl chloride at dose levels in the range of 1 to mg/kg; each point represents 3 independent values. The first one concerns the fate of a dose of vinyl chloride in the mammalian by: Vinylidene chloride is weakly positive in the Salmonella typhimurium TA test, mediated by kidney and liver post-mitochondrial supernatant (S-9 mix) from normal mice, but strongly positive with the S-9 mix from the induced animals.

In the case of mediation by rat tissue, only liver S-9 mix from induced animals affords a significant positive by: Oct 15,  · Evidence for alkylation of DNA has been provided for vinyl chloride, 1 vinylidene chloride, 2 and trichloroethylene 3,4 Rearrangement mechanisms have been studied in detail 5 and found mostly consistent with the spectrum of metabolites found in vivo, 6 and mercapturic acids have been demonstrated as the main metabolites of vinyl and vinylidene Cited by: 5.

The mutagenicity of vinyl chloride, vinylidene chloride (1,1-dichloroethylene) and chloroprene (2-chloro-1,3-butadiene) was tested in V79 Chinese hamster cells in the presence of a 15 × g liver supernatant from phenobarbitone-pre-treated rats and mice. Mutations in terms of 8-azaguanine and ouabain resistance were induced in a dose-related fashion by exposure to vapour of vinyl chloride Cited by: The biological fate of vinylidene chloride in rats.

Chem. Biol. Interact. 20, 27– Google Scholar Kafer, E. and Kappas, A. () Genetic analysis of genotoxic effects on chromosomes and cell division in lower A.

Kappas, V. Cogliano, K. Watanabe, G. Zapponi. The metabolism of inhaled vinylidene chloride in rats represents a balance of biotransformation pathways leading to the formation of a reactive alkylating species which is normally detoxified by conjugation with by: ABSTRACT Vinylidene chloride is toxic to laboratory animals and can be fatal at sufficiently high dose levels.

Liver is the prime target organ of vinylidene chloride in mammals. Hepatic injury can occur rapidly^ after inhalation exposure. Chronic exposure to low levels of vinylidene chloride can result in liver and kidney damage.

Chlorinated aliphatic hydrocarbons constitute a variety of chemically closely related compounds which share one common physical feature: D.

The biological fate of vinylidene chloride in rats. Chem.-Biol. Interact., 20, 27 PubMed CrossRef Google Scholar. Laib, R. and Bolt, H. Buy this book on publisher's site Cited by: 3. Male rats (normally fed or previously fasted for 18 hr) were given a single oral dose of 1 or 50 mg/kg of [14 C]vinylidene chloride (VDC) in corn oil and the routes and rates of elimination of 14 C activity were then followed for 72 a single oral dose of 1 mg/kg of [14 C]VDC, 78% of the dose was metabolized and excreted in urine and feces as nonvolatile metabolites of by: The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites.

The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Oct 15,  · Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Abstract D.E.: The biological fate of vinylidene chloride in rats.

Chem.-biol. Interact. 20, 27–41 () CrossRef Google Covalent Binding of Haloethylenes. In: Snyder R. et al. (eds) Biological Reactive Intermediates—II. Advances in Cited by: 7. 1,1-Dichloroethylene (DCE), also known as vinylidene chloride, DC, 1,1-DCE, and 1,1-dichloroethene, has been used as a chemical intermediate and in the manufacture of poly vinylidene copolymers.

Polymers of DCE and vinyl chloride are used as food wrap (CEH ). DCE is a synthetic chemical with no known natural sources (USEPA ).Cited by: 5. The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites.

The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is by: Exposure of mice to 50,or ppm of vinyl chloride (VC) in the air for 6 h/d, 5 d/wk, caused a high incidence of bronchioloalveolar adenoma, mammary gland tumours, and hemangio & arcoma.

Mammary gland tumours occurred in the females and included ductular adenocarcinoma and squamous and anaplastic cell carcinomas with metastasis to the by: PubMed:The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride.

PubMed:The biological fate in rats of vinyl chloride in relation to its oncogenicity. PubMed:Human, rat and mouse liver-mediated mutagenicity of vinyl chloride in S. typhimurium strains. We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services.

Vinylidene chloride polymers are widely used as food wrappers. This review, with 38 references, covers chemistry, and animal and human toxicology.

Biosensors and Biological Nanotechnology - (WW) mammals mammals Subject Category: Organism Names see more details, Cited by: 9. Drug Metabolism and Disposition will consider for publication manuscripts describing the results of original research that contribute significant and novel information on xenobiotic metabolism.

The present report deals with the early results of carcinogenicity bio-assays of Vinylidene chloride (VDC), weeks from the starting of the experiments, VDC is employed in the production of polymers, whose major use is the manufacturing of flexible packaging for food.

" The monomer has been tested by inhalation on rats (,50, 25, 10 ppm), mice (,50, 25, 10 ppm), and Cited by: Vinylidene chloride was, however, toxic to yeast.

No information was found concerning the toxicity of vinylidene chloride to domestic animals and non- aquatic wildlife. Biological Effects in Animals and Man Vinylidene chloride is readily absorbed by mammals following oral or inhalation exposure. Chlorinated ethylenes are metabolized in mammals, as a first step, to epoxides.

The fate of these electrophilic intermediates may be reaction with nucleophiles (alkylation), hydrolysis, or intramolecular rearrangement. The latter reaction has been studied in the whole series of chlorinated epoxiethanes. 1,1-Dichloroethylene (1,1-dichloroethene, vinylidene chloride, 1,1-DCE) is a clear, colourless liquid with a characteristic sweet odour, a boiling point of approximately 32°C, a high vapour pressure of kPa at 20°C and a Henry's law constant of atm·m 3 /mol.

Footnote 1 Footnote 2 It is soluble in most organic solvents, and its solubility in water is mg/L at 21°C. Toxicity of vinylidene chloride in mice and rats and its alteration by various treatments. Robert D. Short, Potential biological hazards of commercially available cleansers for dentures.

Robert E. Osterberg, Book Reviews. book review. Book review. John S. Krebs & David C. Jones. Fifty-four abstracts of papers that discuss the physical properties, chemical reactions, and toxicity of vinylidene chloride (VDC) are presented. An overview summarizes data on the effects of acute and chronic exposures of rats by inhalation or ingestion, mutagenicity in Salmonella typhimurium, and skin and eye irritation and neurological.

Vinylidene chloride was quantifiable, exceeding approximately 1 mg/m 3 only occasionally (Vinylidene chloride concentrations in the µg/m 3 ( ppb) range were measured at urban sites in New Jersey as part of the Airborne Trace Element and Organic Substances (ATEOS) project [68, 69]. However, the authors.

Vinylidene chloride (VDC) is a groundwater and drinking water contaminant. Monochloroacetic acid (MCA) is a chlorination by-product of drinking water. Because environmental or occupational exposure to chemicals takes place at low concentrations, a sensitive in vitro system of liver slices was used to examine the interactive toxicity of MCA and by: 3.

For this study by the medical department of a large chemical company the authors identified workers who had been exposed to vinylidene chloride (VCl2) but not to vinyl chloride (VCI). In previous studies relating to exposure to VCI and health there had also been some VC12 in the working environment, and although animal experiments had shown VCl2 to be a hepatotoxin no reports on the effects of Cited by:.

Predicting the oral uptake efficiency of chemicals in mammals: Combining the hydrophilic and lipophilic range Article in Toxicology and Applied Pharmacology (1) · November with 57 Reads.Vinylidene chloride is readily absorbed by mammals following oral or inhalation exposure.

the atmospheric fate of vinylidene chloride under physical and chemical removal processes was studied by Cupitt (). No studies were found in the literature searched on the biological effects of vinylidene chloride on microorganisms.Abstract. Within 2 hr after 1,1-dichloroethylene administration, the following phenomena occur in livers of fasted rats: dilation and disruption of bile canaliculi, plasma membrane invagination and loss of microvilli, cytoplasmic vacuolation, and loss of density in mitochondrial by: